The interaction between early life complications and a polygenic risk score for schizophrenia is associated with brain activity during emotion processing in healthy participants.

Veronica Debora ToroLinda A AntonucciTiziana QuartoRoberta PassiatoreLeonardo FazioGianluca UrsiniQiang ChenRita MasellisSilvia TorrettaLeonardo SportelliGianluca Christos KikidisFrancesco MassariEnrico D'AmbrosioAntonio RampinoGiulio PergolaDaniel R WeinbergerAlessandro BertolinoGiuseppe Blasi

Published in: Psychological medicine (2024)

These results suggest that emotion-related VLPFC response lies in the path from genetic and non-genetic risk factors to the clinical presentation of SCZ, and may implicate an updated concept of intermediate phenotype considering early non-genetic factors of risk for SCZ.

Keyphrases

early life
risk factors
genome wide
autism spectrum disorder
depressive symptoms
copy number
bipolar disorder
dna methylation
gene expression
drug induced