Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl 3 model.

Xueying JinXueling YueZhe HuangXiangkun MengShengnan XuYuna WuYing WanAiko InoueMegumi NarisawaLina HuGuo-Ping ShiHiroyuki UmegakiToyoaki MuroharaYanna LeiMasafumi KuzuyaXian Wu Cheng

Published in: Cellular and molecular life sciences : CMLS (2024)

stress, possibly via the modulation of vascular inflammation, oxidative production and apoptosis, suggesting that CTSK could be an effective therapeutic target for CPS-related thrombotic events in patients with CCVDs.

Keyphrases

oxidative stress
pulmonary embolism
cell death
signaling pathway
replacement therapy