Pleiokomenines A and B: Dimeric Aspidofractinine Alkaloids Tethered with a Methylene Group.
Elvis Otogo N'Nang ObiangGrégory Genta-JouveJean-François GallardBrice KumulunguiElisabeth MourayPhilippe GrellierLaurent EvannoErwan PouponPierre ChampyMehdi A BeniddirPublished in: Organic letters (2017)
Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain.
Keyphrases
- molecular docking
- ms ms
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- high intensity
- high resolution
- gas chromatography mass spectrometry
- room temperature
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry
- gas chromatography
- solid phase extraction
- ultra high performance liquid chromatography
- molecular dynamics simulations