The effects of inhaled corticosteroids on healthy airways.

Emanuele MarchiTimothy Stopford Christopher HinksMatthew RichardsonLatifa KhalfaouiFiona A SymonPoojitha RajasekarRachel L CliffordBeverley HargadonCary D AustinJulia L MacIsaacMichael S KoborSalman SiddiquiJordan S MarJoseph R ArronDavid F ChoyPeter Bradding

Published in: Allergy (2024)

In healthy airways, 4-week ICS exposure reduces gene expression related to both innate and adaptive immunity, and reduces markers of type-2 inflammation. This implies that homeostasis in health involves tonic type-2 signalling in the airway mucosa, which is exquisitely sensitive to ICS.

Keyphrases

cystic fibrosis
gene expression
healthcare
oxidative stress
public health
dna methylation
mental health
risk assessment
study protocol
drug induced