Affective Antidepressant, Cytotoxic Activities, and Characterization of Phyto-Assisted Zinc Oxide Nanoparticles Synthesized Using Sanvitalia procumbens Aqueous Extract.
Yasir RashidFozia FoziaIjaz AhmadNisar AhmadMadeeha AslamAmal A AlotaibiPublished in: BioMed research international (2022)
Green synthesis of nanoparticles has emerged as an effective and environmentally friendly method. Therefore, the current investigation is based on the green synthesis of zinc oxide nanoparticles (ZnO-NPs) using plant extract of Sanvitalia procumbens ( S. procumbens ) that act as a capping and reducing agent. S. procumbens is a fast-growing shrub and densely available plant and may have potential to synthesize ZnO-NPs. The synthesized ZnO-NPs were characterized by different techniques, including Fourier transform infrared spectroscopy (FT-IR), UV-visible (UV-Vis), energy-dispersive X-ray (EDX), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The UV-Vis spectrum at 350 nm revealed an absorption peak for the synthesis of ZnO-NPs. In addition, photoactive biomolecules of the prepared ZnO-NPs were identified by using FT-IR spectroscopy. Furthermore, the spherical geometry of ZnO-NPs was evaluated by SEM images. The synthesized ZnO-NPs were also used to enhance the antidepressant activity and exhibited a remarkable reduction in the time of immobility in tail suspension tests (TST) and forced swim tests (FST), as well as increased the BDNF levels in the brain and plasma. ZnO-NPs have a low risk of biocompatibility (cell visibility) at a concentration of 7 g/mL or below. The nanoparticles were biologically compatible when the concentrations were increased up to 11 μ g/mL. It was concluded that ZnO-NPs were investigated as a possible carrier for antidepressant drug delivery into the brain, and their excellent cytotoxic activity was evaluated by using the MTT assay to determine their biocompatibility.
Keyphrases
- oxide nanoparticles
- room temperature
- quantum dots
- electron microscopy
- reduced graphene oxide
- visible light
- light emitting
- high resolution
- drug delivery
- major depressive disorder
- oxidative stress
- single cell
- gold nanoparticles
- deep learning
- white matter
- stem cells
- high throughput
- resting state
- magnetic resonance imaging
- single molecule
- stress induced
- computed tomography
- blood brain barrier
- mass spectrometry
- risk assessment
- brain injury
- convolutional neural network
- low cost
- subarachnoid hemorrhage
- functional connectivity
- optical coherence tomography
- anti inflammatory
- solid phase extraction