Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease.

Badri N VardarajanDaniel J SchaidChristiane ReitzRafael LantiguaMartin MedranoIvonne Z Jiménez-VelázquezJoseph H LeeMahdi GhaniEkaterina RogaevaPeter St George-HyslopRichard P Mayeux

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2014)

The average inbreeding coefficient of this population is significantly higher than that of the general Caucasian populations in North America. The high rate of inbreeding resulting in increased frequency of recessive variants is advantageous for the identification of rare variants associated with late-onset Alzheimer disease.Genet Med 17 8, 639-643.

Keyphrases

late onset
early onset
mild cognitive impairment
copy number
intellectual disability
magnetic resonance imaging
magnetic resonance
genome wide
duchenne muscular dystrophy