Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection.
Kazumoto MurataSenko TsukudaFutoshi SuizuAkihiro KimuraMasaya SugiyamaKoichi WatashiMasayuki NoguchiMasashi MizokamiPublished in: Hepatology (Baltimore, Md.) (2020)
Among NUCs, only ANPs have an additional pharmacological effect modulating LPS-mediated cytokine production, which is expected to produce favorable immune responses toward HBV elimination. This additional immunomodulation by ANPs in PBMCs, as well as IFN-λ3 induction in the gastrointestinal tract, provides insights into HBV treatment.