Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination.

Herminio Joey CardonaAgila SomasundaramDonna M CrabtreeSamantha L GaddOren J Becher

Published in: Brain and behavior (2021)

Our results suggest that embryonic overexpression of hPDGFRA in Olig2- or GFAP-progenitors is deleterious to OPC development and leads to CNS hypomyelination.

Keyphrases

growth factor
cell proliferation
transcription factor
pregnant women
blood brain barrier