Histopathological assessment of optic nerve invasion guided by radiological findings in enucleated globes with retinoblastoma.
Mohammed M AbusayfHind Manaa AlkatanSahar ElkhamarySaleh A AlmesferAzza M Y MaktabiPublished in: BMC ophthalmology (2020)
MRI is found to be less sensitive in evaluating prelaminar and laminar ON invasion (0.0 and 42.9%) compared to post-laminar invasion (88.9%). MRI has generally better specificity in detecting ON invasion irrespective of the invasion level. In our study, obtaining deeper and/or additional histologic sections from the other surface of the tissue block in cases where a post-laminar ON invasion by MRI is found but not confirmed histopathologically in routine sections is essential to avoid missing such an important high-risk feature.