Palladium-Catalyzed Formylation of Arylzinc Reagents with S-Phenyl Thioformate.

The first example of palladium-catalyzed direct formylation of arylzinc reagents using S-phenyl thioformate is reported. The reaction proceeded under mild conditions, allowing high functional group tolerance. In addition, the developed formylation method was used to prepare deuterated and 13C-labeled aryl aldehydes from isotope-labeled S-phenyl thioformates. Moreover, this procedure was applied to an alkenylzinc halide, affording the corresponding enal.