In-depth proteomic analysis reveals unique subtype-specific signatures in human small-cell lung cancer.

Beáta SzeitzZsolt MegyesfalviNicole WoldmarZsuzsanna ValkóAnna SchwendenweinNándor BáránySándor PakuViktória LászlóHelga KissEdina BugyikChristian LangAttila Marcell SzászLuciana PizzattiKrisztina BogosMir Alireza HodaKonrad HoetzeneckerGyörgy Marko-VargaPeter HorvatovichBalázs DomeKarin SchelchMelinda Rezeli

Published in: Clinical and translational medicine (2022)

We report for the first time, the protein expression differences among SCLC subtypes. By shedding light on potential subtype-specific therapeutic vulnerabilities and diagnostic biomarkers, our results may contribute to a better understanding of SCLC biology and the development of novel therapies.

Keyphrases

small cell lung cancer
endothelial cells
induced pluripotent stem cells
genome wide
gene expression
human health
brain metastases
risk assessment
dna methylation
climate change