Neuroprotective effect of PPAR gamma agonist in rat model of autism spectrum disorder: Role of Wnt/β-catenin pathway.

Arushi SandhuKajal RawatVipasha GautamAnil KumarAntika SharmaAlka BhatiaSandeep GroverLokesh SainiLekha Saha

Published in: Progress in neuro-psychopharmacology & biological psychiatry (2024)

In the present study, upregulation of canonical Wnt/β-catenin pathway was demonstrated in ASD rat model. Pioglitazone administration significantly ameliorated these symptoms potentially through its neuroprotective effect and its ability to downregulate the Wnt/β-catenin pathway. The antagonism between the PPARγ and Wnt pathway offers a promising therapeutic approach for addressing ASD.

Keyphrases

autism spectrum disorder
cell proliferation
stem cells
attention deficit hyperactivity disorder
intellectual disability
insulin resistance
cerebral ischemia
type diabetes
metabolic syndrome
sleep quality
brain injury
long non coding rna
blood brain barrier
subarachnoid hemorrhage