TXNIP Suppresses the Osteochondrogenic Switch of VSMCs in Atherosclerosis.

Sang-Ho Woo Dongsoo Kyung Seung Hyun Lee Kyu Seong Park Minkyu Kim Kibyeong KimHyo-Jung KwonYoung-Suk WonInpyo ChoiYoung Jun Park Du-Min Go Jeong-Seop Oh Won Kee YoonSeung Sam PaikJi Hyeon KimYong-Hwan KimJae-Hoon ChoiDae-Yong Kim

Published in: Circulation research (2022)

Our results suggest that TXNIP is a novel regulator of atherosclerotic calcification by suppressing bone morphogenetic protein signaling to inhibit the transition of VSMCs toward an osteochondrogenic phenotype.

Keyphrases

nlrp inflammasome
vascular smooth muscle cells
signaling pathway
cardiovascular disease
chronic kidney disease
transcription factor
angiotensin ii
type diabetes