A novel mechanism of ACE inhibition-associated enhanced platelet reactivity: disproof of the ARB-MI paradox?
Carolin HeltenPhilipp MourikisLisa DannenbergRené M'PembeleKajetan TrojovskyAysel AyhanChristina KohlmorgenMaria GrandochBodo LevkauVerena VeulemansTobias PetzoldThomas HohlfeldMalte KelmTobias ZeusPhilipp MourikisPublished in: European journal of clinical pharmacology (2020)
ACEI enhanced platelet reactivity. This can be reversed by changing to ARB. The mechanism behind RAAS influencing platelet function seems to be associated with PAR-1 expression.