Pyrrolo[2,1- a ]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes via an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process. This reaction was promoted by a four-component catalytic system which included [RuCl 2 ( p -cymene)] 2 , CuCl, copper acetate monohydrate and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) under aerobic conditions.