ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers.

Jake J ReskeMike R WilsonBrooke ArmisteadShannon HarkinsCristina PerezJoel HritMarie AdamsScott B RothbartStacey A MissmerAsgerally T FazleabasRonald L Chandler

Published in: BMC biology (2022)

These studies demonstrate that ARID1A-containing BAF complexes are required for maintenance of the histone variant H3.3 at active regulatory elements, such as super-enhancers, and this function is required for the physiologically relevant activities of alternative chromatin remodelers.

Keyphrases

transcription factor
dna damage
gene expression
genome wide
dna methylation
case control