DNA Methylation Profiling of Human Hepatocarcinogenesis.

Gabriela Hernandez-Meza Johann von FeldenEdgar E Gonzalez-KozlovaTeresa Garcia-LezanaJudit PeixAnna PortelaAmanda J CraigSergi SayolsMyron SchwartzBojan LosicVincenzo MazzaferroManel EstellerJosep M LlovetAugusto Villanueva

Published in: Hepatology (Baltimore, Md.) (2021)

Genome-wide DNA-methylation profiles accurately discriminate the different histological stages of human hepatocarcinogenesis. We report on epigenetic gatekeepers in the transition between dysplastic nodules and eHCC. DNA-methylation changes in cirrhotic tissue correlate with clinical outcomes.

Keyphrases

dna methylation
genome wide
endothelial cells
gene expression
induced pluripotent stem cells
copy number
single cell