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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy.

Hiren Y DandiaMamatha M PillaiDeepak SharmaMeghna SuvarnaNeha DalalAyush MadhokArvind IngleShubhada V ChiplunkarSanjeev GalandePrakriti Tayalia
Published in: Military Medical Research (2024)
Our scaffold-based T-cell therapy presents an innovative in situ localized approach for programming T-cells to target solid tumors. This approach offers a viable alternative to in vitro manipulation of T-cells, circumventing the need for large-scale in vitro generation and culture of tumor-specific T-cells. It offers an off-the-shelf alternative that facilitates the use of host cells instead of allogeneic cells, thereby, overcoming a major hurdle.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • stem cell transplantation
  • bone marrow
  • endoplasmic reticulum stress
  • signaling pathway
  • tissue engineering
  • oxidative stress
  • gene expression