Validation and iteration of CT perfusion defined malignant profile thresholds for acute ischemic stroke.
Kevin J KeenanSoren ChristensenManabu InoueMichael MlynashGregory W AlbersWade S SmithPublished in: International journal of stroke : official journal of the International Stroke Society (2019)
We validated the ability of published CTP Tmax lesion volume thresholds to predict poor outcomes despite IV-tPA in an independent cohort using only 4 cm of CTP anatomical coverage. A CBF > 39 mL threshold, rather than the predominantly 8 cm CTP coverage derived CBF threshold of >53 mL, was associated with poor outcomes in this 4 cm CTP coverage cohort.