Inhibition of autophagy significantly increases the antitumor effect of Abiraterone in prostate cancer.

Ashkan MortezaviSouzan SalemiBenedikt KranzbühlerOliver GrossTullio SulserHans-Uwe SimonDaniel Eberli

Published in: World journal of urology (2018)

AA activates autophagy as a cytoprotective mechanism in LNCaP prostate cancer cells and targeting of autophagy enhances the antitumor effect of the compound.

Keyphrases

prostate cancer
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
radical prostatectomy