The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study.

Amin Gharbi-MelianiAline DugravotSéverine SabiaMelina RegyAurore FayosseAlexis SchnitzlerMika KivimäkiArchana Singh-ManouxJulien Dumurgier

Published in: Alzheimer's research & therapy (2021)

Both heterozygous and homozygous ε4 carriers had poorer cognition and greater risk of dementia at older ages. Our findings show some support for a complex antagonist pleiotropic effect of APOE ε4 heterozygosity over the adult life course, characterized by cognitive advantage in midlife.

Keyphrases

mild cognitive impairment
cognitive decline
cognitive impairment
high fat diet
risk factors
physical activity
early onset
type diabetes
community dwelling
skeletal muscle