Several Plasmodium vivax relapses after correct primaquine treatment in a patient with impaired cytochrome P450 2D6 function.
Alexandra Martin RamírezCarlos Lombardia GonzálezTamara Soler ManiegaÁngela Gutierrez LiarteDiego Domingo GarcíaMarta Lanza SuárezMaría Josefa Bernal FernándezJose Miguel Rubio MuñozPublished in: Malaria journal (2020)
The impairment in CYP2D6 enzyme could be the most likely cause of P. vivax relapses in this patient. This highlights the importance of considering the analysis of CYP2D6 gene polymorphisms in cases of P. vivax relapses after a correct treatment and, especially, it should be considered in any study of dosage and duration of primaquine treatment.
Keyphrases