Chronic Binge Alcohol Exposure During Pregnancy Alters mTOR System in Rat Fetal Hippocampus.

Jehoon LeeRaine Lunde-YoungVishal NaikJosue RamirezMarcus OrzabalJayanth Ramadoss

Published in: Alcoholism, clinical and experimental research (2020)

We conclude that chronic binge alcohol exposure during pregnancy alters mTORC1 signaling pathway in the fetal hippocampus. We conjecture that this dysregulation of mTOR protein expression, its activity, and downstream proteins may play a critical role in FASD neurobiological phenotypes.

Keyphrases

signaling pathway
cell proliferation
alcohol consumption
cognitive impairment
cerebral ischemia
pi k akt
oxidative stress
prefrontal cortex
induced apoptosis
blood brain barrier
spectrum disorder