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Intensity of MRI Gadolinium Enhancement in Cerebral Adrenoleukodystrophy: A Biomarker for Inflammation and Predictor of Outcome following Transplantation in Higher Risk Patients.

Weston P MillerLuiz Fernando Alves Lima MantovaniJ MuzicJeffrey B RykkenRakhee S GawandeTroy C LundRyan ShanleyG V RaymondPaul J OrchardDavid R Nascene
Published in: AJNR. American journal of neuroradiology (2015)
Gadolinium enhancement intensity on brain MR imaging can be scored simply and reproducibly for cerebral adrenoleukodystrophy. The enhancement score significantly correlates with chitotriosidase. In boys with higher risk cerebral disease (Loes ≥10), the enhancement score itself predicts neurologic outcome following treatment. Such data may help guide treatment decisions for clinicians and families.
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