Intensity of MRI Gadolinium Enhancement in Cerebral Adrenoleukodystrophy: A Biomarker for Inflammation and Predictor of Outcome following Transplantation in Higher Risk Patients.

Weston P Miller Luiz Fernando Alves Lima Mantovani J Muzic Jeffrey B Rykken Rakhee S Gawande Troy C Lund Ryan Shanley G V Raymond Paul J Orchard David R Nascene

Published in: AJNR. American journal of neuroradiology (2015)

Gadolinium enhancement intensity on brain MR imaging can be scored simply and reproducibly for cerebral adrenoleukodystrophy. The enhancement score significantly correlates with chitotriosidase. In boys with higher risk cerebral disease (Loes ≥10), the enhancement score itself predicts neurologic outcome following treatment. Such data may help guide treatment decisions for clinicians and families.

Keyphrases

contrast enhanced
subarachnoid hemorrhage
end stage renal disease
cerebral ischemia
magnetic resonance imaging
ejection fraction
oxidative stress
newly diagnosed
high intensity
chronic kidney disease
computed tomography
machine learning
artificial intelligence
replacement therapy
functional connectivity