Proteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection.
Ishan ParanjpePushkala JayaramanChen-Yang SuSirui ZhouSteven ChenRyan C ThompsonDiane Marie Del ValleEphraim KenigsbergShan P ZhaoSuraj K JaladankiKumardeep ChaudharySteven AscolilloAkhil VaidEdgar G KozlovaJustin KauffmanArvind KumarManish ParanjpeRoss O HaganSamir KamatFaris F GulamaliHui XieJoceyln HarrisManishkumar PatelKimberly ArguetaCraig BatchelorKai NieSergio DellepianeLeisha ScottMatthew A LevinJohn Cijiang HeMayte Suárez-FariñasSteven G CocaLili ChanEvren U AzelogluEric E SchadtNoam D BeckmannSacha GnjaticMiriam MeradSeunghee Kim-SchulzeJohn Brent RichardsBenjamin Scott GlicksbergAlexander W CharneyGirish Nitin NadkarniPublished in: Communications medicine (2023)
Using clinical and proteomic data, our results suggest that while both acute and long-term COVID-associated kidney dysfunction are associated with markers of tubular dysfunction, AKI is driven by a largely multifactorial process involving hemodynamic instability and myocardial damage.
Keyphrases
- oxidative stress
- end stage renal disease
- ejection fraction
- coronavirus disease
- sars cov
- chronic kidney disease
- newly diagnosed
- liver failure
- acute kidney injury
- peritoneal dialysis
- prognostic factors
- big data
- machine learning
- heart failure
- electronic health record
- respiratory syndrome coronavirus
- label free
- aortic dissection
- atrial fibrillation
- extracorporeal membrane oxygenation