Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming.

Naoko HattoriKiyoshi AsadaNozomu MiyajimaAkiko MoriYoko NakanishiKana KimuraMika WakabayashiHideyuki TakeshimaChika NitaniJunichi HaraToshikazu Ushijima

Published in: British journal of cancer (2021)

Epigenetic drug-based differentiation therapy using 5-aza-dC and TBT is a promising strategy for refractory NBLs.

Keyphrases

dna methylation
drug induced
high glucose
gene expression
diabetic rats
dendritic cells
emergency department
stem cells
oxidative stress
immune response
adverse drug
mesenchymal stem cells
bone marrow
electronic health record