Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model.

Isabella Iwanicki Lydia L WuFernando Flores-GuzmanRachael SundlandPaula Viza-GomesRachel NordgrenConnor S CentnerJessica J KandelMark A ApplebaumKenneth B Bader Sonia L Hernandez

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2023)

In addition to ablative effects, histotripsy was found to drive tumor apoptosis through intrinsic pathways, altering blood vessel architecture, and reducing hypoxia.

Keyphrases

endothelial cells
endoplasmic reticulum stress
oxidative stress
cell death
cell cycle arrest