Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition.

Tingting ZouYuka SatoShuma KaneyoshiKota ManoRui YasukawaYoshifumi NakanoSatoshi Fujii Shinobu SatoShigeori Takenaka

Published in: Molecules (Basel, Switzerland) (2022)

Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.

Keyphrases

capillary electrophoresis
mass spectrometry
dna binding
transcription factor
nucleic acid