Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide-Induced Cystitis by Promoting Microglia Activation and Neuroinflammation.
Jia-Liang ChenHonglu DingBolong LiuXiangfu ZhouXin ZhouZhijun LinFei YangHailun ZhanHengjun XiaoPublished in: Mediators of inflammation (2021)
Notch1 signaling contributes to mechanical allodynia associated with CYP-induced cystitis by promoting microglia activation and neuroinflammation. Our study showed that inhibition of Notch1 signaling might have therapeutic value for treating pain symptoms in BPS/IC.
Keyphrases
- neuropathic pain
- high glucose
- inflammatory response
- diabetic rats
- lipopolysaccharide induced
- spinal cord
- traumatic brain injury
- spinal cord injury
- chronic pain
- lps induced
- drug induced
- low dose
- cognitive impairment
- endothelial cells
- high dose
- oxidative stress
- physical activity
- brain injury
- sleep quality
- postoperative pain
- stress induced