Clinicogenomic characterization of prostate cancer liver metastases.

Mohammed AlshalalfaCrystal SeldonIdalid FrancoRandy A VinceRuben CarmonaSanoj PunnenSalma Kaochar Robert T Dess Amar U Kishan Daniel E SprattJanaki SharmaAlan Dal PraAlan PollackMatthew C AbramowitzBrandon A Mahal

Published in: Prostate cancer and prostatic diseases (2022)

Liver metastases in prostate cancer are associated with poor survival and aggressive genomic features, including MYC-amplification, PTEN-deletion, and PIK3CB-amplification. These findings could have prognostic, treatment, and trial implications.

Keyphrases

liver metastases
prostate cancer
radical prostatectomy
nucleic acid
clinical trial
cell proliferation
study protocol
phase iii
transcription factor
pi k akt
phase ii
copy number
signaling pathway
open label