Peripheral signature of altered synaptic integrity in young onset Cannabis Use Disorder: A proteomic study of circulating extracellular vesicles.
Suhas GaneshTuKiet T LamRolando García MilianDeepak D'SouzaAngus C NairnKatya ElgertErez EitanMohini RanganathanPublished in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2023)
In this pilot study, we noted a decrease in SHANK1 protein, involved in the structural and functional integrity of glutamatergic post-synapse, a potential peripheral signature of CUD neuropathology. The study shows that LFQ mass spectrometry proteomic analysis of NDEs derived from plasma may yield important insights into the synaptic pathology associated with CUD.