Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm.
Thomas AlbrechtAnnik RossbergFabian RoseKai BreuhahnEva-Marie BaumannMarcell TóthFritz BrinkmannAlphonse CharbelMonika Nadja VogelBruno KöhlerArianeb MehrabiMarkus Wolfgang BüchlerStephan SingerWiebke SolassBeate StraubPeter SchirmacherStephanie RoesslerBenjamin GoeppertPublished in: Journal of clinical pathology (2024)
In conclusion, we propose a sequential diagnostic approach for iCCA, integrating CRP immunohistochemistry and Alb-ISH. This may improve the accuracy of CCA classification and pave the way towards a molecular-guided CCA classification.