Functional connectivity in cognitive control networks mitigates the impact of white matter lesions in the elderly.
Gloria BensonAndrea HildebrandtCatharina LangeClaudia SchwarzTheresa KöbeWerner SommerAgnes FlöelMiranka WirthPublished in: Alzheimer's research & therapy (2018)
Higher functional connectivity in fronto-parietal and salience networks may protect against detrimental effects of WML on executive functions, the cognitive domain that was predominantly affected by cerebrovascular pathology. These results highlight the crucial role of cognitive control networks as a neural substrate of cognitive reserve in older individuals.