Influence of genetic polymorphisms on mechanical pain sensitivity and endogenous pain modulation of trigeminal and spinal areas.

Flávia Fonseca Carvalho SoaresDyna Mara Araújo Oliveira FerreiraAmanda Ayla RaimundiniThiago José DionísioCarlos Ferreira Dos SantosPaulo César Rodrigues Conti Yuri Martins CostaLeonardo Rigoldi Bonjardim

Published in: Journal of oral rehabilitation (2022)

Genetic polymorphisms had a slight contribution to endogenous pain modulation as indicated by the significant association with WUR but did not contribute to mechanical pain sensitivity. On the other hand, the presence of painful TMD and the sleep quality contributed significantly to mechanical pain sensitivity.

Keyphrases

chronic pain
neuropathic pain
pain management
sleep quality
spinal cord
depressive symptoms