Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis.

Yunwei WangKuo ShenYulin SunPeng CaoJia ZhangWanfu ZhangYang LiuHao ZhangYang ChenShaohui LiChaolei XuChao HanYating QiaoQingyi ZhangBin WangLiang LuoYunshu YangHao Guan

Published in: Burns & trauma (2023)

3D cultivation can be utilized as an innovative optimization strategy to effectively develop DPC-derived EVs for the treatment of skin wounds. tdDPC-EVs significantly enhance wound healing via KLF4/VEGFA-driven angiogenesis.

Keyphrases

wound healing
vascular endothelial growth factor
endothelial cells
induced apoptosis
cell cycle arrest
oxidative stress
cell death
combination therapy
replacement therapy