Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas.
Xiaoqiang SunXiaoping LiuMengxue XiaYongzhao ShaoXiaohua Douglas ZhangPublished in: Journal of translational medicine (2019)
The multicellular gene network approach developed herein indicates profound roles of the macrophage-mediated tumor microenvironment in the progression and drug resistance of gliomas. The identified macrophage-related gene signature has good prognostic value for predicting resistance to targeted therapeutics and survival of glioma patients, implying that combining current targeted therapies with new macrophage-targeted therapy may be beneficial for the long-term treatment outcomes of glioma patients.
Keyphrases
- end stage renal disease
- genome wide
- adipose tissue
- network analysis
- newly diagnosed
- copy number
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- high grade
- prognostic factors
- dna methylation
- transcription factor
- genome wide identification
- patient reported outcomes
- patient reported
- intellectual disability
- cancer therapy