Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.

Nana AkinoOsamu Hiraike-WadaWataru IsonoHiromi TeraoHarunori HonjoYuichiro MiyamotoMichihiro TanikawaKenbun SoneMana HiranoMiyuki HaradaTetsuya HirataYasushi HirotaKaori KogaKatsutoshi OdaTomoyuki FujiiYutaka Osuga

Published in: Reproductive biology and endocrinology : RB&E (2019)

Our data suggest that DMF administration activates the Nrf2/Keap1 pathway, elevate levels of antioxidants, and decrease DNA damage and oxidative stress, resulting in improved ovarian reserve in the mouse ovary.

Keyphrases

oxidative stress
dna damage
diabetic rats
ischemia reperfusion injury
induced apoptosis
protein protein
dna repair
electronic health record
mouse model
machine learning
heat shock
type diabetes
small molecule
polycystic ovary syndrome
deep learning