Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and Undefined CD45 Negative Cells.
Victor H HuPhilip J LuthertTamsyn DerrickJames PullinHelen A WeissPatrick MassaeTara MtuyWilliam MakupaDavid EssexDavid C W MabeyRobin L BaileyMartin J HollandMatthew J BurtonPublished in: PLoS neglected tropical diseases (2016)
These data point to the infiltration of immune cells with a phenotype suggestive of NK cells in conjunctival trachomatous scarring. A large proportion of CD45 negative inflammatory cells were also present. Future work should seek to understand the stimuli leading to the recruitment of these cells and their role in progressive scarring.