High Positive End-Expiratory Pressure Renders Spontaneous Effort Noninjurious.

Caio C A MoraisYukiko KoyamaTakeshi YoshidaGlauco M PlensSusimeire GomesCristhiano A S LimaOzires P S RamosSérgio M PereiraNaomasa KawaguchiHirofumi YamamotoAkinori UchiyamaJoão B BorgesMarcos F Vidal MeloMauro R TucciMarcelo B P AmatoBrian P KavanaghEduardo L V CostaYuji Fujino

Published in: American journal of respiratory and critical care medicine (2019)

Strong effort increased dependent lung injury, where higher local lung stress and stretch was generated; effort-dependent lung injury was minimized by high PEEP in severe ARDS, which may offset need for paralysis.

Keyphrases

mechanical ventilation
acute respiratory distress syndrome
early onset
extracorporeal membrane oxygenation
drug induced