The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Lorie MarchittoJonathan RichardJérémie PrévostAlexandra TauzinDerek YangTa-Jung ChiuHung-Ching ChenMarco A Díaz-SalinasManon NayracMehdi BenlarbiGuillaume Beaudoin-BussièresSai Priya AnandKatrina DionneÉtienne BélangerDebashree ChatterjeeHalima MedjahedCatherine BourassaWilliam D TolbertBeatrice H HahnJames B MunroMarzena PazgierAmos B SmithAndrés FinziPublished in: bioRxiv : the preprint server for biology (2024)
The elimination of HIV-1-infected cells remains an important medical goal. While current antiretroviral therapy decreases viral loads below detection levels, it does not eliminate latently infected cells which form the viral reservoir. Here, we developed a cocktail of non-neutralizing antibodies targeting highly conserved Env regions and combined it with a potent indoline CD4mc. This combination exhibited very potent ADCC activity against HIV-1-infected primary CD4+ T cells as well as monocyte-derived macrophages, suggesting its potential utility in decreasing the size of the viral reservoir.
Keyphrases
- hiv infected
- antiretroviral therapy
- induced apoptosis
- sars cov
- human immunodeficiency virus
- cell cycle arrest
- hiv infected patients
- hiv aids
- healthcare
- anti inflammatory
- transcription factor
- nk cells
- cancer therapy
- dendritic cells
- endoplasmic reticulum stress
- oxidative stress
- endothelial cells
- high glucose
- immune response
- hepatitis c virus
- dengue virus
- real time pcr
- sensitive detection