Comprehensive characterization of plasma cell-free Echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing.

Jingkai JiBin LiJingzhong LiWangmu DanzengJiandong LiYanping ZhaoGezhen QiangbaQingda ZhangNibu RenzhenZhuoga BasangChanglin JiaQuzhen GongsangJinmin MaYicong WangFang ChenHongcheng Zhounull HuasangJiefang YinJiandan XieNa PeiHuimin CaiHuayan JiangHuanming YangJian Wangnull AsanXiumin HanJunhua LiWeijun ChenDong Yang

Published in: PLoS neglected tropical diseases (2020)

With ultra-high-throughput sequencing technology, we analyzed the concentration, fragment length, release source, and other characteristics of cell-free Echinococcus spp. DNA in the plasma of echinococcosis patients. A better understanding of the characteristics of cell-free Echinococcus spp. DNA in plasma may facilitate their future application as a biomarker for diagnosis.

Keyphrases

cell free
circulating tumor
end stage renal disease
high throughput sequencing
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
circulating tumor cells