Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: The Generation R Study.

Kirsten I M LoomanEvelien R van MeelChristina Grosserichter-WagenerFloor J M VissersJanice H KlingenbergNicolette W de JongJohan C de JongsteSuzanne G M A PasmansLiesbeth DuijtsMenno C van ZelmHenriëtte A Moll

Published in: Allergy (2019)

Children with any atopic disease and children with inhalant- and food-allergic sensitization or atopic dermatitis had higher circulating memory Treg cells, but not higher IgE+ B-cell numbers. The associations of higher Treg and CD27+ IgA+ B-cell numbers in children with food-allergic sensitization are suggestive of TGF-β-mediated compensation for chronic inflammation.

Keyphrases

atopic dermatitis
young adults
induced apoptosis
oxidative stress
cell cycle arrest
cell death
risk assessment
human health
climate change
epithelial mesenchymal transition