Serum uromodulin is inversely associated with biomarkers of subclinical inflammation in the population-based KORA F4 study.

Cornelia ThenChristian HerderHolger ThenBarbara ThorandCornelia HuthMargit HeierChrista MeisingerAnnette PetersWolfgang KoenigWolfgang RathmannMichael RodenMichael StumvollHaifa MaalmiThomas MeitingerAndreas LechnerJürgen ScherberichJochen Seissler

Published in: Clinical kidney journal (2020)

sUmod was inversely associated with biomarkers of subclinical inflammation in older participants of the KORA F4 study. The association of sUmod with IL-6 differed between women and men. Future research should focus on whether the immunomodulatory properties of sUmod are one explanation for the association of sUmod with cardiovascular outcomes and mortality.

Keyphrases

oxidative stress
middle aged
physical activity
type diabetes
polycystic ovary syndrome
current status
community dwelling