The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
Jiayi LiuWei LiKe-Qiong DengSong TianHui LiuHongjie ShiQian FangZhen LiuZe ChenTian TianShanyu GanFengjiao HuManli HuXu ChengYan-Xiao JiPeng ZhangZhi-Gang SheXiao-Jing ZhangShao-Ze ChenJingjing CaiHong Liang LiPublished in: Circulation research (2022)
Our findings provide the first evidence supporting Trim16 as a novel suppressor of pathological cardiac hypertrophy and indicate that targeting the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.