A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer.
Madeline A DorsoPayal T PatelAleksandr PankovJacob A BoyerRajesh Kumar SoniIsabella S Del PrioreOmar HayattAmanda KulickConnor J HagenElisa De StanchinaMelissa R JunttilaAnneleen DaemenLori S FriedmanRonald C HendricksonSarat ChandarlapatyPublished in: Cancer research communications (2023)
NSCLC is the leading cause of cancer deaths worldwide. There is a need to identify novel druggable dependencies. We identify a subset of NSCLCs dependent on FOXA1-GR and sensitive to GR antagonism.