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Cilostazol Mediates Immune Responses and Affects Angiogenesis During the Acute Phase of Hind Limb Ischemia in a Mouse Model.

Efthymios C ParonisMichalis KatsimpoulasNikolaos P E KadoglouClaire ProvostMarianna StasinopoulouChristos SpyropoulosElpida PoulakiAurelie PrignonIoannis KakisisNikolaos G KostomitsopoulosPenelope BouziotisIoannis V KostopoulosOurania TsitsilonisAndreas Lazaris
Published in: Journal of cardiovascular pharmacology and therapeutics (2020)
Cilostazol seems to significantly increase angiogenesis in wild-type animals during the first postoperational week. It also influences immune cells, altering the type of immune response by promoting anti-inflammatory cytokine production in wild-type animals, while it helps toward inflammation regression in immunodeficient animals.
Keyphrases
  • wild type
  • immune response
  • mouse model
  • endothelial cells
  • anti inflammatory
  • vascular endothelial growth factor
  • oxidative stress
  • dendritic cells
  • toll like receptor
  • clinical trial