Cilostazol Mediates Immune Responses and Affects Angiogenesis During the Acute Phase of Hind Limb Ischemia in a Mouse Model.
Efthymios C ParonisMichalis KatsimpoulasNikolaos P E KadoglouClaire ProvostMarianna StasinopoulouChristos SpyropoulosElpida PoulakiAurelie PrignonIoannis KakisisNikolaos G KostomitsopoulosPenelope BouziotisIoannis V KostopoulosOurania TsitsilonisAndreas LazarisPublished in: Journal of cardiovascular pharmacology and therapeutics (2020)
Cilostazol seems to significantly increase angiogenesis in wild-type animals during the first postoperational week. It also influences immune cells, altering the type of immune response by promoting anti-inflammatory cytokine production in wild-type animals, while it helps toward inflammation regression in immunodeficient animals.