Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains.

Elissavet KentepozidouSarah J AitkenChristine FeigKlara StefflovaXimena Ibarra-SoriaDuncan T OdomMaša RollerPaul Flicek

Published in: Genome biology (2020)

Dynamic conservation of CTCF site clusters is an apparently important feature of CTCF binding evolution that is critical to the functional stability of a higher-order chromatin structure.

Keyphrases

genome wide
dna binding
gene expression
dna damage
machine learning
transcription factor
binding protein
dna methylation