Epidermal Growth Factor Receptor Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage in Mice.
Fumi NakanoHideki KanamaruFumihiro KawakitaLei LiuYoshinari NakatsukaHirofumi NishikawaTakeshi OkadaHidenori SuzukiPublished in: Stroke (2023)
Activated EGFR, nuclear-NIK, and NFκB expressions were observed in cortical degenerating neurons after SAH, and were decreased by administration of AG1478, associated with suppression of TUNEL- and cleaved caspase-3-positive neurons. EGFR/NIK/NFκB pathway is suggested to be involved in neuronal apoptosis after SAH in mice.
Keyphrases
- epidermal growth factor receptor
- subarachnoid hemorrhage
- cerebral ischemia
- oxidative stress
- tyrosine kinase
- advanced non small cell lung cancer
- cell cycle arrest
- cell death
- brain injury
- signaling pathway
- pi k akt
- endoplasmic reticulum stress
- high fat diet induced
- lps induced
- spinal cord
- induced apoptosis
- small cell lung cancer
- nuclear factor
- blood brain barrier
- insulin resistance
- quantum dots
- immune response
- metabolic syndrome
- skeletal muscle