Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.

Jing-Yi HeDai-Di LiQian WenTing-Yang QinHong LongShi-Bin ZhangFeng Zhang

Published in: CNS neuroscience & therapeutics (2023)

Neuroinflammation and oxidative stress synergistically aggravated DA neuronal loss. Furtherly, oxidative stress followed by neuroinflammation caused more DA neuronal loss than neuroinflammation followed by oxidative stress.

Keyphrases

oxidative stress
cerebral ischemia
lps induced
lipopolysaccharide induced
traumatic brain injury
dna damage
diabetic rats
subarachnoid hemorrhage
ischemia reperfusion injury
inflammatory response
cognitive impairment
induced apoptosis
brain injury
blood brain barrier
uric acid