Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis.

Marcel NaumannKevin PeikertRene GüntherAnneke J van der KooiEleonora AronicaAnnemarie HübersVeronique DanelPhilippe CorciaFrancisco Pan-MontojoSebahattin CirakGöknur HalilogluAlbert C LudolphAnand GoswamiPeter M AndersenJohannes PrudloFlorian WegnerPhilip Van DammeJochen H WeishauptAndreas Hermann

Published in: Annals of clinical and translational neurology (2019)

We report the largest genotype-phenotype correlation of FUS-ALS, which enables a careful prediction of the clinical course in newly diagnosed patients. In this cohort, FUS-ALS patients did not have an increased risk for malignant diseases.

Keyphrases

newly diagnosed
amyotrophic lateral sclerosis
end stage renal disease
ejection fraction
dna methylation
genome wide
copy number
patient reported